Elizabeth Blackburn, PhD

Professor
Biochemistry and Biophysics
+1 415 476-7284

Dr. Elizabeth H. Blackburn, Morris Herztein Professor of Biology and Physiology in the Department of Biochemistry and Biophysics at the University of California, San Francisco, is a leader in the area of telomere and telomerase research.

She discovered the molecular nature of telomeres - the ends of eukaryotic chromosomes that serve as protective caps essential for preserving the genetic information - and the ribonucleoprotein enzyme, telomerase. Blackburn and her research team at the University of California, San Francisco are working with various cells including human cells, with the goal of understanding telomerase and telomere biology.

Blackburn earned her B.Sc. (1970) and M.Sc. (1972) degrees from the University of Melbourne in Australia, and her Ph.D. (1975) from the University of Cambridge in England. She did her postdoctoral work in Molecular and Cellular Biology from 1975 to 1977 at Yale.

In 1978, Blackburn joined the faculty at the University of California at Berkeley in the Department of Molecular Biology. In 1990, she joined the Department of Microbiology and Immunology at UC San Francisco, where she served as Department Chair from 1993 to 1999. Blackburn is currently a faculty member in Department of Biochemistry and Biophysics at UCSF. She is also a Non-Resident Fellow of the Salk Institute.

Throughout her career, Blackburn has been honored by her peers as the recipient of many prestigious awards. She was elected President of the American Society for Cell Biology for the year 1998. Blackburn is an elected Fellow of the American Academy of Arts and Sciences (1991), the Royal Society of London (1992), the American Academy of Microbiology (1993), and the American Association for the Advancement of Science (2000).

She was elected Foreign Associate of the National Academy of Sciences in 1993, and was elected as a Member of the Institute of Medicine in 2000. She was awarded the Albert Lasker Medical Research Award in Basic Medical Research (2006). In 2007 she was named one of TIME Magazine’s 100 Most influential People and she is the 2008 North American Laureate for L’Oreal-UNESCO For Women in Science.

Publications: 

Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation.

Brain, behavior, and immunity

Lazarides C, Epel ES, Lin J, Blackburn EH, Voelkle MC, Buss C, Simhan HN, Wadhwa PD, Entringer S

An investigation of racial/ethnic and sex differences in the association between experiences of everyday discrimination and leukocyte telomere length among patients with coronary artery disease.

Psychoneuroendocrinology

Sullivan S, Hammadah M, Al Mheid I, Shah A, Sun YV, Kutner M, Ward L, Blackburn E, Zhao J, Lin J, Bremner JD, Quyyumi AA, Vaccarino V, Lewis TT

Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.

Nature communications

Chow TT, Shi X, Wei JH, Guan J, Stadler G, Huang B, Blackburn EH

In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study.

Psychoneuroendocrinology

Lin J, Sun J, Wang S, Milush JM, Baker CAR, Coccia M, Effros RB, Puterman E, Blackburn E, Prather AA, Epel E

Chronic Obesity and Incident Hypertension in Latina Women Are Associated with Accelerated Telomere Length Loss over a 1-Year Period.

Metabolic syndrome and related disorders

Wojcicki JM, Elwan D, Lin J, Blackburn E, Epel E

Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults.

Neurobiology of aging

Staffaroni AM, Tosun D, Lin J, Elahi FM, Casaletto KB, Wynn MJ, Patel N, Neuhaus J, Walters SM, Epel ES, Blackburn EH, Kramer JH

Validation of Minimally-Invasive Sample Collection Methods for Measurement of Telomere Length.

Frontiers in aging neuroscience

Stout SA, Lin J, Hernandez N, Davis EP, Blackburn E, Carroll JE, Glynn LM

Socioeconomic Status, Financial Strain, and Leukocyte Telomere Length in a Sample of African American Midlife Men.

Journal of racial and ethnic health disparities

Schrock JM, Adler NE, Epel ES, Nuru-Jeter AM, Lin J, Blackburn EH, Taylor RJ, Chae DH

Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings.

Journal of psychosomatic research

Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM

The Longitudinal Relationship Between Cortisol Responses to Mental Stress and Leukocyte Telomere Attrition.

The Journal of clinical endocrinology and metabolism

Steptoe A, Hamer M, Lin J, Blackburn EH, Erusalimsky JD

Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults.

PLoS medicine

Rehkopf DH, Needham BL, Lin J, Blackburn EH, Zota AR, Wojcicki JM, Epel ES

Leukocyte telomere length and ideal cardiovascular health in American Indians: the Strong Heart Family Study.

European journal of epidemiology

Peng H, Mete M, Desale S, Fretts AM, Cole SA, Best LG, Lin J, Blackburn E, Lee ET, Howard BV, Zhao J

HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis.

PloS one

Auld E, Lin J, Chang E, Byanyima P, Ayakaka I, Musisi E, Worodria W, Davis JL, Segal M, Blackburn E, Huang L

Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects.

Viruses

Usadi B, Bruhn R, Lin J, Lee TH, Blackburn E, Murphy EL

Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study.

Aging

Peng H, Zhu Y, Yeh F, Cole SA, Best LG, Lin J, Blackburn E, Devereux RB, Roman MJ, Lee ET, Howard BV, Zhao J

Early exclusive breastfeeding is associated with longer telomeres in Latino preschool children.

The American journal of clinical nutrition

Wojcicki JM, Heyman MB, Elwan D, Lin J, Blackburn E, Epel E

Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report.

Molecular neuropsychiatry

Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM

Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal change.

Molecular genetics and genomics : MGG

Wojcicki JM, Shiboski S, Heyman MB, Elwan D, Lin J, Blackburn E, Epel E

Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes.

Journal of immunology research

Lin J, Cheon J, Brown R, Coccia M, Puterman E, Aschbacher K, Sinclair E, Epel E, Blackburn EH

Transforming Cancer Prevention through Precision Medicine and Immune-oncology.

Cancer prevention research (Philadelphia, Pa.)

Kensler TW, Spira A, Garber JE, Szabo E, Lee JJ, Dong Z, Dannenberg AJ, Hait WN, Blackburn E, Davidson NE, Foti M, Lippman SM

Movement-Based Behaviors and Leukocyte Telomere Length among US Adults.

Medicine and science in sports and exercise

Loprinzi PD, Loenneke JP, Blackburn EH

Association of dimensional psychological health measures with telomere length in male war veterans.

Journal of affective disorders

Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM

Q&A: End-game winner.

Nature

Blackburn E, Tucker E

Discrimination, mental health, and leukocyte telomere length among African American men.

Psychoneuroendocrinology

Chae DH, Epel ES, Nuru-Jeter AM, Lincoln KD, Taylor RJ, Lin J, Blackburn EH, Thomas SB

Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002.

Epidemiology (Cambridge, Mass.)

Needham BL, Rehkopf D, Adler N, Gregorich S, Lin J, Blackburn EH, Epel ES

Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.

Progress in neuro-psychopharmacology & biological psychiatry

Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.

Genetics

Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP, Rowell S, Sadler M, Sakoda LC, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Risch N, Schaefer C, Blackburn EH

Maternal Folate Concentration in Early Pregnancy and Newborn Telomere Length.

Annals of nutrition & metabolism

Entringer S, Epel ES, Lin J, Blackburn EH, Buss C, Shahbaba B, Gillen DL, Venkataramanan R, Simhan HN, Wadhwa PD

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.

Neuroscience and biobehavioral reviews

Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM

Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample.

Journal of health and social behavior

Geronimus AT, Pearson JA, Linnenbringer E, Schulz AJ, Reyes AG, Epel ES, Lin J, Blackburn EH

Early telomerase inactivation accelerates aging independently of telomere length.

Cell

Xie Z, Jay KA, Smith DL, Zhang Y, Liu Z, Zheng J, Tian R, Li H, Blackburn EH

PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.

Psychiatry research

Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S

Maternal estriol concentrations in early gestation predict infant telomere length.

The Journal of clinical endocrinology and metabolism

Entringer S, Epel ES, Lin J, Blackburn EH, Buss C, Simhan HN, Wadhwa PD

Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis.

Journal of molecular biology

Fraser JA, Worrall EG, Lin Y, Landre V, Pettersson S, Blackburn E, Walkinshaw M, Muller P, Vojtesek B, Ball K, Hupp TR

Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and women.

Brain, behavior, and immunity

Prather AA, Gurfein B, Moran P, Daubenmier J, Acree M, Bacchetti P, Sinclair E, Lin J, Blackburn E, Hecht FM, Epel ES

Associations of cadmium and lead exposure with leukocyte telomere length: findings from National Health and Nutrition Examination Survey, 1999-2002.

American journal of epidemiology

Zota AR, Needham BL, Blackburn EH, Lin J, Park SK, Rehkopf DH, Epel ES

Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging.

Circulation. Arrhythmia and electrophysiology

Roberts JD, Dewland TA, Longoria J, Fitzpatrick AL, Ziv E, Hu D, Lin J, Glidden DV, Psaty BM, Burchard EG, Blackburn EH, Olgin JE, Heckbert SR, Marcus GM

Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults.

Journal of affective disorders

Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM

Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study.

Aging

Chen S, Yeh F, Lin J, Matsuguchi T, Blackburn E, Lee ET, Howard BV, Zhao J

Short leukocyte telomere length predicts incidence and progression of carotid atherosclerosis in American Indians: the Strong Heart Family Study.

Aging

Chen S, Lin J, Matsuguchi T, Blackburn E, Yeh F, Best LG, Devereux RB, Lee ET, Howard BV, Roman MJ, Zhao J

Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources.

Proceedings of the National Academy of Sciences of the United States of America

Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A

Metabolic profiles of biological aging in American Indians: the Strong Heart Family Study.

Aging

Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, Howard BV

Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: A population-based observational study.

American journal of human biology : the official journal of the Human Biology Council

Rehkopf DH, Dow WH, Rosero-Bixby L, Lin J, Epel ES, Blackburn EH

Discrimination, racial bias, and telomere length in African-American men.

American journal of preventive medicine

Chae DH, Nuru-Jeter AM, Adler NE, Brody GH, Lin J, Blackburn EH, Epel ES

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.

Cell

Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B

Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study.

The Lancet. Oncology

Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, Marlin R, Frenda SJ, Magbanua MJM, Daubenmier J, Estay I, Hills NK, Chainani-Wu N, Carroll PR, Blackburn EH

QTL mapping of leukocyte telomere length in American Indians: the Strong Heart Family Study.

Aging

Zhu Y, Voruganti VS, Lin J, Matsuguchi T, Blackburn E, Best LG, Lee ET, MacCluer JW, Cole SA, Zhao J

Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: a population-based study.

Experimental gerontology

Rehkopf DH, Dow WH, Rosero-Bixby L, Lin J, Epel ES, Blackburn EH

Short leukocyte telomere length predicts risk of diabetes in american indians: the strong heart family study.

Diabetes

Zhao J, Zhu Y, Lin J, Matsuguchi T, Blackburn E, Zhang Y, Cole SA, Best LG, Lee ET, Howard BV

Multisystem resiliency moderates the major depression-telomere length association: findings from the Heart and Soul Study.

Brain, behavior, and immunity

Puterman E, Epel ES, Lin J, Blackburn EH, Gross JJ, Whooley MA, Cohen BE

Visualization of actin filaments and monomers in somatic cell nuclei.

Molecular biology of the cell

Belin BJ, Cimini BA, Blackburn EH, Mullins RD

Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002.

Social science & medicine (1982)

Needham BL, Adler N, Gregorich S, Rehkopf D, Lin J, Blackburn EH, Epel ES

Accelerated cell aging in female APOE-e4 carriers: implications for hormone therapy use.

PloS one

Jacobs EG, Kroenke C, Lin J, Epel ES, Kenna HA, Blackburn EH, Rasgon NL

Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort.

Experimental gerontology

Dowd JB, Bosch JA, Steptoe A, Blackburn EH, Lin J, Rees-Clayton E, Aiello AE

Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length.

American journal of obstetrics and gynecology

Entringer S, Epel ES, Lin J, Buss C, Shahbaba B, Blackburn EH, Simhan HN, Wadhwa PD

Association between kidney function and telomere length: the heart and soul study.

American journal of nephrology

Bansal N, Whooley MA, Regan M, McCulloch CE, Ix JH, Epel E, Blackburn E, Lin J, Hsu CY

Telomeres and adversity: Too toxic to ignore.

Nature

Blackburn EH, Epel ES

Chronic stress elevates telomerase activity in rats.

Biology letters

Beery AK, Lin J, Biddle JS, Francis DD, Blackburn EH, Epel ES

Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial.

Brain, behavior, and immunity

Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E

The telomere syndromes.

Nature reviews. Genetics

Armanios M, Blackburn EH

Educational attainment and late life telomere length in the Health, Aging and Body Composition Study.

Brain, behavior, and immunity

Adler N, Pantell MS, O'Donovan A, Blackburn E, Cawthon R, Koster A, Opresko P, Newman A, Harris TB, Epel E

Socioeconomic status and cell aging in children.

Social science & medicine (1982)

Needham BL, Fernandez JR, Lin J, Epel ES, Blackburn EH

Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length.

Brain, behavior, and immunity

O'Donovan A, Tomiyama AJ, Lin J, Puterman E, Adler NE, Kemeny M, Wolkowitz OM, Blackburn EH, Epel ES

Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study.

Psychoneuroendocrinology

Daubenmier J, Lin J, Blackburn E, Hecht FM, Kristeller J, Maninger N, Kuwata M, Bacchetti P, Havel PJ, Epel E

Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length.

Physiology & behavior

Tomiyama AJ, O'Donovan A, Lin J, Puterman E, Lazaro A, Chan J, Dhabhar FS, Wolkowitz O, Kirschbaum C, Blackburn E, Epel E

Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study.

PloS one

Krauss J, Farzaneh-Far R, Puterman E, Na B, Lin J, Epel E, Blackburn E, Whooley MA

Telomerase, telomere length, and coronary artery calcium in black and white men in the CARDIA study.

Atherosclerosis

Kroenke CH, Pletcher MJ, Lin J, Blackburn E, Adler N, Matthews K, Epel E

Shorter leukocyte telomere length in midlife women with poor sleep quality.

Journal of aging research

Prather AA, Puterman E, Lin J, O'Donovan A, Krauss J, Tomiyama AJ, Epel ES, Blackburn EH

Hostility and cellular aging in men from the Whitehall II cohort.

Biological psychiatry

Brydon L, Lin J, Butcher L, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A

Actuary of the cell. Interview by Thea Singer.

Scientific American

Blackburn EH

Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children.

Psychosomatic medicine

Kroenke CH, Epel E, Adler N, Bush NR, Obradovic J, Lin J, Blackburn E, Stamperdahl JL, Boyce WT

Telomeres and lifestyle factors: roles in cellular aging.

Mutation research

Lin J, Epel E, Blackburn E

Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR.

Nucleic acids research

Aviv A, Hunt SC, Lin J, Cao X, Kimura M, Blackburn E

Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood.

Proceedings of the National Academy of Sciences of the United States of America

Entringer S, Epel ES, Kumsta R, Lin J, Hellhammer DH, Blackburn EH, Wüst S, Wadhwa PD

Cancer interception.

Cancer prevention research (Philadelphia, Pa.)

Blackburn EH

Depression and leukocyte telomere length in patients with coronary heart disease: data from the Heart and Soul Study.

Psychosomatic medicine

Hoen PW, de Jonge P, Na BY, Farzaneh-Far R, Epel E, Lin J, Blackburn E, Whooley MA

Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study.

PloS one

O'Donovan A, Pantell MS, Puterman E, Dhabhar FS, Blackburn EH, Yaffe K, Cawthon RM, Opresko PL, Hsueh WC, Satterfield S, Newman AB, Ayonayon HN, Rubin SM, Harris TB, Epel ES

Telomerase: an RNP enzyme synthesizes DNA.

Cold Spring Harbor perspectives in biology

Blackburn EH, Collins K

Educational attainment but not measures of current socioeconomic circumstances are associated with leukocyte telomere length in healthy older men and women.

Brain, behavior, and immunity

Steptoe A, Hamer M, Butcher L, Lin J, Brydon L, Kivimäki M, Marmot M, Blackburn E, Erusalimsky JD

Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder.

Biological psychiatry

O'Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S, Metzler T, Lenoci M, Blackburn E, Neylan TC

Walking the walk from genes through telomere maintenance to cancer risk.

Cancer prevention research (Philadelphia, Pa.)

Blackburn EH

Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.

PloS one

Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, Blackburn EH

Telomere shortening in formerly abused and never abused women.

Biological research for nursing

Humphreys J, Epel ES, Cooper BA, Lin J, Blackburn EH, Lee KA

Intensive meditation training, immune cell telomerase activity, and psychological mediators.

Psychoneuroendocrinology

Jacobs TL, Epel ES, Lin J, Blackburn EH, Wolkowitz OM, Bridwell DA, Zanesco AP, Aichele SR, Sahdra BK, MacLean KA, King BG, Shaver PR, Rosenberg EL, Ferrer E, Wallace BA, Saron CD

Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline.

Brain research

Lin J, Kroenke CH, Epel E, Kenna HA, Wolkowitz OM, Blackburn E, Rasgon NL

Telomeres and telomerase: the means to the end (Nobel lecture).

Angewandte Chemie (International ed. in English)

Blackburn EH

A common variant in the telomerase RNA component is associated with short telomere length.

PloS one

Njajou OT, Blackburn EH, Pawlikowska L, Mangino M, Damcott CM, Kwok PY, Spector TD, Newman AB, Harris TB, Cummings SR, Cawthon RM, Shuldiner AR, Valdes AM, Hsueh WC

A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53.

The Journal of biological chemistry

Fraser JA, Madhumalar A, Blackburn E, Bramham J, Walkinshaw MD, Verma C, Hupp TR

Characterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition site.

The Journal of biological chemistry

Williams TL, Levy DL, Maki-Yonekura S, Yonekura K, Blackburn EH

The power of exercise: buffering the effect of chronic stress on telomere length.

PloS one

Puterman E, Lin J, Blackburn E, O'Donovan A, Adler N, Epel E

Highlighting the science of cancer prevention.

Cancer prevention research (Philadelphia, Pa.)

Blackburn EH

Unprecedented opportunities and promise for cancer prevention research.

Cancer prevention research (Philadelphia, Pa.)

Blackburn EH, Tlsty TD, Lippman SM

Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease.

JAMA

Farzaneh-Far R, Lin J, Epel ES, Harris WS, Blackburn EH, Whooley MA

Dynamics of telomerase activity in response to acute psychological stress.

Brain, behavior, and immunity

Epel ES, Lin J, Dhabhar FS, Wolkowitz OM, Puterman E, Karan L, Blackburn EH

2009 Nobels: break or breakthrough for women? Interview by Jeffrey Mervis and Kate Travis.

Science (New York, N.Y.)

Blackburn E, Greider C, Yonath A, Ostrom E

Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.

Journal of immunological methods

Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E

Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres.

Annals of the New York Academy of Sciences

Epel E, Daubenmier J, Moskowitz JT, Folkman S, Blackburn E

Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study.

The journals of gerontology. Series A, Biological sciences and medical sciences

Njajou OT, Hsueh WC, Blackburn EH, Newman AB, Wu SH, Li R, Simonsick EM, Harris TM, Cummings SR, Cawthon RM

Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.

Cell

Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat KM, Blackburn EH

Mec1 function in the DNA damage response does not require its interaction with Tel2.

Cell cycle (Georgetown, Tex.)

Anderson CM, Blackburn EH

The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men.

Aging

Epel ES, Merkin SS, Cawthon R, Blackburn EH, Adler NE, Pletcher MJ, Seeman TE

Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy.

Epigenetics & chromatin

Wang X, Kam Z, Carlton PM, Xu L, Sedat JW, Blackburn EH

Dietary restraint and telomere length in pre- and postmenopausal women.

Psychosomatic medicine

Kiefer A, Lin J, Blackburn E, Epel E

Increased telomerase activity and comprehensive lifestyle changes: a pilot study.

The Lancet. Oncology

Ornish D, Lin J, Daubenmier J, Weidner G, Epel E, Kemp C, Magbanua MJ, Marlin R, Yglecias L, Carroll PR, Blackburn EH

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

Genes & development

Anderson CM, Korkin D, Smith DL, Makovets S, Seidel JJ, Sali A, Blackburn EH

Telomere length is paternally inherited and is associated with parental lifespan.

Proceedings of the National Academy of Sciences of the United States of America

Njajou OT, Cawthon RM, Damcott CM, Wu SH, Ott S, Garant MJ, Blackburn EH, Mitchell BD, Shuldiner AR, Hsueh WC

Telomerase core components protect Candida telomeres from aberrant overhang accumulation.

Proceedings of the National Academy of Sciences of the United States of America

Hsu M, McEachern MJ, Dandjinou AT, Tzfati Y, Orr E, Blackburn EH, Lue NF

Genes and pathways downstream of telomerase in melanoma metastasis.

Proceedings of the National Academy of Sciences of the United States of America

Bagheri S, Nosrati M, Li S, Fong S, Torabian S, Rangel J, Moore DH, Federman S, Laposa RR, Baehner FL, Sagebiel RW, Cleaver JE, Haqq C, Debs RJ, Blackburn EH, Kashani-Sabet M

Cell aging in relation to stress arousal and cardiovascular disease risk factors.

Psychoneuroendocrinology

Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE, Dolbier C, Mendes WB, Blackburn EH

Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita.

Blood

Ly H, Schertzer M, Jastaniah W, Davis J, Yong SL, Ouyang Q, Blackburn EH, Parslow TG, Lansdorp PM

Stem cell science and politics: a talk with Elizabeth Blackburn.

Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees

Blackburn E

Thoughts of a former Council member.

Perspectives in biology and medicine

Blackburn E

Accelerated telomere shortening in response to life stress.

Proceedings of the National Academy of Sciences of the United States of America

Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM

A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein.

Proceedings of the National Academy of Sciences of the United States of America

Lin J, Ly H, Hussain A, Abraham M, Pearl S, Tzfati Y, Parslow TG, Blackburn EH

Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA.

Clinical cancer research : an official journal of the American Association for Cancer Research

Nosrati M, Li S, Bagheri S, Ginzinger D, Blackburn EH, Debs RJ, Kashani-Sabet M

Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions.

Molecular and cellular biology

Makovets S, Herskowitz I, Blackburn EH

Bioethics and the political distortion of biomedical science.

The New England journal of medicine

Blackburn E

Reason as our guide.

PLoS biology

Blackburn E, Rowley J

Telomeres and telomerase.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Chan SR, Blackburn EH

Tracking telomerase.

Cell

Greider CW, Blackburn EH

A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.

RNA (New York, N.Y.)

Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR

Comprehensive structure-function analysis of the core domain of human telomerase RNA.

Molecular and cellular biology

Ly H, Blackburn EH, Parslow TG

A novel pseudoknot element is essential for the action of a yeast telomerase.

Genes & development

Tzfati Y, Knight Z, Roy J, Blackburn EH

A molecular switch underlies a human telomerase disease.

Proceedings of the National Academy of Sciences of the United States of America

Comolli LR, Smirnov I, Xu L, Blackburn EH, James TL

A bulged stem tethers Est1p to telomerase RNA in budding yeast.

Genes & development

Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR

Harmful moratorium on stem cell research.

Science (New York, N.Y.)

Rowley JD, Blackburn E, Gazzaniga MS, Foster DW

The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America

Nautiyal S, DeRisi JL, Blackburn EH

Dynamics of telomeric DNA turnover in yeast.

Genetics

McEachern MJ, Underwood DH, Blackburn EH

A Trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity.

The Journal of biological chemistry

Cano MI, Blake JJ, Blackburn EH, Agabian N