Jue Lin, Ph.D.
Dr. Jue Lin graduated from Fudan University, Shanghai, China in 1992. She went to Cornell University for her Ph.D., studying self-splicing ribozymes in yeast. She joined Dr. Elizabeth Blackburn’s lab for her postdoctoral training in 1999. While in Dr. Blackburn’s lab, she initially worked on various aspects of yeast telomerase regulation, including the template region of the RNA component of telomerase, discovery of a universal RNA core structure for telomerase RNA and a novel mechanism for how the protein PinX1p inhibits telomerase activity. In 2003, she, together with Drs. Liz Blackburn, Elissa Epel and Richard Cawthon, pioneered the work that showed psychological stress was associated with shorter telomere length and lower telomerase activity. Her research focuses on telomere maintenance in health and disease, using a variety of approaches, including in vitro and ex vivo cell culture models, animal models, as well as clinical studies. She currently serves as the Director of the Telomere Core in the Blackburn lab. The core has collaborated with over 90 research teams from50institutions (US and7othercountries)over the last 17years, resulting in over 150scientific papers. She is a PI of one of theU01 awards under the Telomere Research Network, a NIA and NIEHS sponsored network dedicated to facilitating the collaboration between basic telomere biologists, population and exposure researchers, and other scientists across disciplines to advance inter disciplinary research on telomeres as sentinels of environment exposure, psychosocial stress and disease susceptibility.
Publications
Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study.
JAMA neurology
Foo JN, Chew EGY, Chung SJ, Peng R, Blauwendraat C, Nalls MA, Mok KY, Satake W, Toda T, Chao Y, Tan LCS, Tandiono M, Lian MM, Ng EY, Prakash KM, Au WL, Meah WY, Mok SQ, Annuar AA, Chan AYY, Chen L, Chen Y, Jeon BS, Jiang L, Lim JL, Lin JJ, Liu C, Mao C, Mok V, Pei Z, Shang HF, Shi CH, Song K, Tan AH, Wu YR, Xu YM, Xu R, Yan Y, Yang J, Zhang B, Koh WP, Lim SY, Khor CC, Liu J, Tan EK
Evaluating Mild Cognitive Dysfunction in Patients with Parkinson's Disease in Clinical Practice in Taiwan.
Scientific reports
Yu RL, Lee WJ, Li JY, Chang YY, Chen CC, Lin JJ, Sung YF, Lin TK, Fuh JL
Telomere length measurement by qPCR - Summary of critical factors and recommendations for assay design.
Psychoneuroendocrinology
Lin J, Smith DL, Esteves K, Drury S
In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study.
Psychoneuroendocrinology
Lin J, Sun J, Wang S, Milush JM, Baker CAR, Coccia M, Effros RB, Puterman E, Blackburn E, Prather AA, Epel E
Variability of presynaptic nigrostriatal dopaminergic function and clinical heterogeneity in a dopa-responsive dystonia family with GCH-1 gene mutation.
Journal of neurology
Lin JJ, Lu CS, Tsai CH
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.
Neurobiology of aging
Wang L, Heckman MG, Aasly JO, Annesi G, Bozi M, Chung SJ, Clarke C, Crosiers D, Eckstein G, Garraux G, Hadjigeorgiou GM, Hattori N, Jeon B, Kim YJ, Kubo M, Lesage S, Lin JJ, Lynch T, Lichtner P, Mellick GD, Mok V, Morrison KE, Quattrone A, Satake W, Silburn PA, Stefanis L, Stockton JD, Tan EK, Toda T, Brice A, Van Broeckhoven C, Uitti RJ, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM, Gasser T, Krüger R, Farrer MJ, Ross OA, Sharma M
PDD-5S: A useful screening tool for Parkinson's disease dementia.
Parkinsonism & related disorders
Lee WJ, Wu SL, Li JY, Chen CC, Lin JJ, Peng GS, Lin TK, Wang SJ, Chen RS, Yang YH, Tsai CH, Hsu JL, Liao YC, Chen SP, Fuh JL
Large-scale assessment of polyglutamine repeat expansions in Parkinson disease.
Neurology
Wang L, Aasly JO, Annesi G, Bardien S, Bozi M, Brice A, Carr J, Chung SJ, Clarke C, Crosiers D, Deutschländer A, Eckstein G, Farrer MJ, Goldwurm S, Garraux G, Hadjigeorgiou GM, Hicks AA, Hattori N, Klein C, Jeon B, Kim YJ, Lesage S, Lin JJ, Lynch T, Lichtner P, Lang AE, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE, Opala G, Pihlstrøm L, Pramstaller PP, Park SS, Quattrone A, Rogaeva E, Ross OA, Stefanis L, Stockton JD, Silburn PA, Theuns J, Tan EK, Tomiyama H, Toft M, Van Broeckhoven C, Uitti RJ, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Yueh KC, Zhao Y, Gasser T, Maraganore DM, Krüger R, Sharma M
Prevalence and risk factors of cognitive impairment in Parkinson disease: a population-based case-control study in Taiwan.
Medicine
Huang YC, Wu ST, Lin JJ, Lin CC, Kao CH
TREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study.
Parkinsonism & related disorders
Ortega-Cubero S, Lorenzo-Betancor O, Lorenzo E, Agúndez JA, Jiménez-Jiménez FJ, Ross OA, Wurster I, Mielke C, Lin JJ, Coria F, Clarimon J, Ezquerra M, Brighina L, Annesi G, Alonso-Navarro H, García-Martin E, Gironell A, Marti MJ, Yueh KC, Wszolek ZK, Sharma M, Berg D, Krüger R, Pastor MA, Pastor P
Spinocerebellar ataxia 35: novel mutations in TGM6 with clinical and genetic characterization.
Neurology
Guo YC, Lin JJ, Liao YC, Tsai PC, Lee YC, Soong BW
Comparison of activities of daily living impairments in Parkinson's disease patients as defined by the Pill Questionnaire and assessments by neurologists.
Journal of neurology, neurosurgery, and psychiatry
Lee WJ, Chang YY, Lin JJ, Sung YF, Li JY, Wang SJ, Chen RS, Yang YH, Hu CJ, Tsai CH, Wang HC, Wu SL, Chang MH, Fuh JL
Reversible oro-lingual dyskinesia related to lithium intoxication.
Acta neurologica Taiwanica
Chen WY, Chen AC, Tsai SJ, Lin JJ
A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants.
Journal of medical genetics
Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Bertram L, Bozi M, Barcikowska M, Crosiers D, Clarke CE, Facheris MF, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon BS, Jamrozik Z, Krygowska-Wajs A, Lesage S, Lill CM, Lin JJ, Lynch T, Lichtner P, Lang AE, Libioulle C, Murata M, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE, Meitnger T, Zimprich A, Opala G, Pramstaller PP, Pichler I, Park SS, Quattrone A, Rogaeva E, Ross OA, Stefanis L, Stockton JD, Satake W, Silburn PA, Strom TM, Theuns J, Tan EK, Toda T, Tomiyama H, Uitti RJ, Van Broeckhoven C, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Yomono HS, Yueh KC, Zhao Y, Gasser T, Maraganore D, Krüger R
Familial paroxysmal nonkinesigenic dyskinesia: clinical and genetic analysis of a Taiwanese family.
Journal of the neurological sciences
Yeh TH, Lin JJ, Lai SC, Wu-Chou YH, Chen AC, Yueh KC, Chen RS, Lu CS
Large-scale replication and heterogeneity in Parkinson disease genetic loci.
Neurology
Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Van Broeckhoven C, Bertram L, Bozi M, Crosiers D, Clarke C, Facheris M, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon B, Lesage S, Lill CM, Lin JJ, Lynch T, Lichtner P, Lang AE, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE, Opala G, Pramstaller PP, Pichler I, Park SS, Quattrone A, Rogaeva E, Ross OA, Stefanis L, Stockton JD, Satake W, Silburn PA, Theuns J, Tan EK, Toda T, Tomiyama H, Uitti RJ, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Yueh KC, Zhao Y, Gasser T, Maraganore D, Krüger R
Telomeres and lifestyle factors: roles in cellular aging.
Mutation research
Lin J, Epel E, Blackburn E
Generalized chorea in the syndrome of acute bilateral basal ganglia lesions in patients with diabetic uremia.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Lin JJ
Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan.
The New England journal of medicine
Chen P, Lin JJ, Lu CS, Ong CT, Hsieh PF, Yang CC, Tai CT, Wu SL, Lu CH, Hsu YC, Yu HY, Ro LS, Lu CT, Chu CC, Tsai JJ, Su YH, Lan SH, Sung SF, Lin SY, Chuang HP, Huang LC, Chen YJ, Tsai PJ, Liao HT, Lin YH, Chen CH, Chung WH, Hung SI, Wu JY, Chang CF, Chen L, Chen YT, Shen CY
High frequency of multiexonic deletion of the GCH1 gene in a Taiwanese cohort of dopa-response dystonia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Wu-Chou YH, Yeh TH, Wang CY, Lin JJ, Huang CC, Chang HC, Lai SC, Chen RS, Weng YH, Huang CL, Lu CS
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.
Neurobiology of aging
Krüger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Klein C, Lambert JC, Lesage S, Lin JJ, Lynch T, Mellick GD, de Nigris F, Opala G, Prigione A, Quattrone A, Ross OA, Satake W, Silburn PA, Tan EK, Toda T, Tomiyama H, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM
Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.
Journal of immunological methods
Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E
Safety/Tolerability and efficacy of rivastigmine in taiwanese patients with Alzheimer's disease: a prospective post-marketing surveillance study.
Clinical drug investigation
Chiu PY, Dai DE, Hsu HP, Lee C, Lin JJ, Kuo HC, Huang YC, Liu YC, Tsai CP
5,10-methylenetetrahydrofolate reductase C677T gene polymorphism can influence age at onset of Parkinson's disease.
Acta neurologica Taiwanica
Lin JJ, Yueh KC, Liu CS, Liu JT, Lin SZ
Genetic polymorphism of the angiotensin converting enzyme and L-dopa-induced adverse effects in Parkinson's disease.
Journal of the neurological sciences
Lin JJ, Yueh KC, Lin SZ, Harn HJ, Liu JT
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.
Pharmacogenetics and genomics
Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT
Homozygous deletion genotype of angiotensin converting enzyme confers protection against migraine in man.
Acta neurologica Taiwanica
Lin JJ, Wang PJ, Chen CH, Yueh KC, Lin SZ, Harn HJ
Lumbar zygapophyseal joint injections in patients with chronic lower back pain.
Journal of the Chinese Medical Association : JCMA
Shih C, Lin GY, Yueh KC, Lin JJ
Camptocormia in Parkinson's disease.
Acta neurologica Taiwanica
Lin JJ
Improvement of generalised dystonia by olanzapine treatment.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Lin JJ, Chang DC
The homozygote 10-copy genotype of variable number tandem repeat dopamine transporter gene may confer protection against Parkinson's disease for male, but not to female patients.
Journal of the neurological sciences
Lin JJ, Yueh KC, Chang DC, Chang CY, Yeh YH, Lin SZ
Association between genetic polymorphism of angiotensin-converting enzyme gene and Parkinson's disease.
Journal of the neurological sciences
Lin JJ, Yueh KC, Chang DC, Lin SZ