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Selected Lab Publications

Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.
Chow TT, Shi X, Wei JH, Guan J, Stadler G, Huang B, Blackburn EH. Nat Commun. 2018 Sep 4;9(1):3583. doi: 10.1038/s41467-018-05840-y. PMID: 30181605 

Early telomerase inactivation accelerates aging independently of telomere length.
Xie Z, Jay KA, Smith DL, Zhang Y, Liu Z, Zheng J, Tian R, Li H, Blackburn EH. Cell. 2015 Feb 26;160(5):928-939. doi: 10.1016/j.cell.2015.02.002. PMID: 25723167 

An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.
Gazzaniga FS, Blackburn EH. Blood. 2014 Dec 11;124(25):3675-84. doi: 10.1182/blood-2014-06-582254. Epub 2014 Oct 15. PMID: 25320237

The telomere syndromes.
Armanios M, Blackburn EH. Nat Rev Genet. 2012 Oct;13(10):693-704. doi: 10.1038/nrg3246. Epub 2012 Sep 11. PMID: 22965356 Free PMC article. Review.

Telomeres and adversity: Too toxic to ignore.
Blackburn EH, Epel ES. Nature. 2012 Oct 11;490(7419):169-71. doi: 10.1038/490169a. PMID: 23060172 

Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.
Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat KM, Blackburn EH. Cell. 2009 Jan 9;136(1):50-61. doi: 10.1016/j.cell.2008.11.027. PMID: 19135888 

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging.
Blackburn EH, Greider CW, Szostak JW. Nat Med. 2006 Oct;12(10):1133-8. doi: 10.1038/nm1006-1133. PMID: 17024208 

Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining.
Chan SW, Blackburn EH. Mol Cell. 2003 May;11(5):1379-87. doi: 10.1016/s1097-2765(03)00174-6. PMID: 12769860

The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae.
Nautiyal S, DeRisi JL, Blackburn EH. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9316-21. doi: 10.1073/pnas.142162499. Epub 2002 Jun 25. PMID: 12084816 

Template boundary in a yeast telomerase specified by RNA structure.
Tzfati Y, Fulton TB, Roy J, Blackburn EH. Science. 2000 May 5;288(5467):863-7. doi: 10.1126/science.288.5467.863. PMID: 10797010

Telomerase in kinetoplastid parasitic protozoa.
Cano MI, Dungan JM, Agabian N, Blackburn EH. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3616-21. doi: 10.1073/pnas.96.7.3616. PMID: 10097086 

The rate of telomere sequence loss in human leukocytes varies with age.
Frenck RW Jr, Blackburn EH, Shannon KM. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5607-10. doi: 10.1073/pnas.95.10.5607. PMID: 9576930 

Block in anaphase chromosome separation caused by a telomerase template mutation.
Kirk KE, Harmon BP, Reichardt IK, Sedat JW, Blackburn EH. Science. 1997 Mar 7;275(5305):1478-81. doi: 10.1126/science.275.5305.1478. PMID: 9045613

Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats.
Krauskopf A, Blackburn EH. Nature. 1996 Sep 26;383(6598):354-7. doi: 10.1038/383354a0. PMID: 8848051

Runaway telomere elongation caused by telomerase RNA gene mutations.
McEachern MJ, Blackburn EH. Nature. 1995 Aug 3;376(6539):403-9. doi: 10.1038/376403a0. PMID: 7630414

Telomerase in yeast.
Cohn M, Blackburn EH. Science. 1995 Jul 21;269(5222):396-400. doi: 10.1126/science.7618104. PMID: 7618104

Architecture of telomerase RNA.
Bhattacharyya A, Blackburn EH.EMBO J. 1994 Dec 1;13(23):5721-31. doi: 10.1002/j.1460-2075.1994.tb06910.x. PMID: 7988568 

An alternative pathway for yeast telomere maintenance rescues est1- senescence.
Lundblad V, Blackburn EH. Cell. 1993 Apr 23;73(2):347-60. doi: 10.1016/0092-8674(93)90234-h. PMID: 8477448

A conserved secondary structure for telomerase RNA.
Romero DP, Blackburn EH. Cell. 1991 Oct 18;67(2):343-53. doi: 10.1016/0092-8674(91)90186-3. PMID: 1840508

Developmentally programmed healing of chromosomes by telomerase in Tetrahymena.
Yu GL, Blackburn EH. Cell. 1991 Nov 15;67(4):823-32. doi: 10.1016/0092-8674(91)90077-c. PMID: 1934071

Structure and function of telomeres.
Blackburn EH. Nature. 1991 Apr 18;350(6319):569-73. doi: 10.1038/350569a0. PMID: 1708110 Review

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.
Yu GL, Bradley JD, Attardi LD, Blackburn EH. Nature. 1990 Mar 8;344(6262):126-32. doi: 10.1038/344126a0. PMID: 1689810

Functional evidence for an RNA template in telomerase.
Shippen-Lentz D, Blackburn EH. Science. 1990 Feb 2;247(4942):546-52. doi: 10.1126/science.1689074. PMID: 1689074

telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
Greider CW, Blackburn EH. Nature. 1989 Jan 26;337(6205):331-7. doi: 10.1038/337331a0. PMID: 2463488

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity.
Greider CW, Blackburn EH. Cell. 1987 Dec 24;51(6):887-98. doi: 10.1016/0092-8674(87)90576-9. PMID: 3319189

Dynamics of telomere length variation in Tetrahymena thermophila.
Larson DD, Spangler EA, Blackburn EH. Cell. 1987 Jul 31;50(3):477-83. doi: 10.1016/0092-8674(87)90501-0. PMID: 3607876

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
Greider CW, Blackburn EH. Cell. 1985 Dec;43(2 Pt 1):405-13. doi: 10.1016/0092-8674(85)90170-9. PMID: 3907856

DNA sequences of telomeres maintained in yeast.
Shampay J, Szostak JW, Blackburn EH. Nature. 1984 Jul 12-18;310(5973):154-7. doi: 10.1038/310154a0. PMID: 6330571

Identification of a telomeric DNA sequence in Trypanosoma brucei.
Blackburn EH, Challoner PB. Cell. 1984 Feb;36(2):447-57. doi: 10.1016/0092-8674(84)90238-1. PMID: 6319025

Cloning yeast telomeres on linear plasmid vectors.
Szostak JW, Blackburn EH. Cell. 1982 May;29(1):245-55. doi: 10.1016/0092-8674(82)90109-x. PMID: 6286143

Allele-specific, selective amplification of a ribosomal RNA gene in Tetrahymena thermophila.
Pan WC, Orias E, Flacks M, Blackburn EH. Cell. 1982 Mar;28(3):595-604. doi: 10.1016/0092-8674(82)90214-8. PMID: 6280878

Sequence-specific fragmentation of macronuclear DNA in a holotrichous ciliate.
Katzen AL, Cann GM, Blackburn EH. Cell. 1981 May;24(2):313-20. doi: 10.1016/0092-8674(81)90321-4. PMID: 6786754

Single extrachromosomal ribosomal RNA gene copies are synthesized during amplification of the rDNA in Tetrahymena.
Pan WC, Blackburn EH. Cell. 1981 Feb;23(2):459-66. doi: 10.1016/0092-8674(81)90141-0. PMID: 7471208

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena.
Blackburn EH, Gall JG. J Mol Biol. 1978 Mar 25;120(1):33-53. doi: 10.1016/0022-2836(78)90294-2. PMID: 642006